期刊
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
卷 40, 期 1, 页码 121-123出版社
WILEY-BLACKWELL
DOI: 10.1111/jcpt.12229
关键词
BRAF mutation; melanoma; targeted therapy; V600M
What is known and objectiveThe management of metastatic melanoma has changed significantly in the past decade with the development of immunotherapies and targeted molecular therapies. Trials of targeted therapies have focused mainly on patients with the most common BRAF V600 mutations, namely V600E/K substitutions, with very little information available on the benefit of targeted therapies on less commonly occurring mutations such as V600R/D and M. Case summaryWe present a 54-year-old man with metastatic melanoma harbouring a rare BRAF V600M mutation, who experienced clinical and radiological response to combined therapy with the BRAF inhibitor dabrafenib and MEK inhibitor trametinib. What is new and conclusionAs our understanding of these therapies evolves and an increasing number of patients have mutational testing performed, there is a clear imperative - as highlighted by this case - to test for rarer mutations and facilitate their inclusion both in everyday practice and in future clinical trials.
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