期刊
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
卷 33, 期 2, 页码 211-214出版社
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2710.2008.00903.x
关键词
cerebellar; epilepsy; interactions; phenytoin; toxicity
We present a series of cases of phenytoin toxicity where the diagnosis was initially missed. These patients all suffered unnecessary morbidity or investigations. The side-effects and unusual pharmacokinetics of phenytoin are discussed, as well as the array of potential drug interactions. We remind clinicians that phenytoin toxicity can easily mimic a cerebellar lesion or alcohol intoxication, and suggest that in accordance with National Institute for Clinical Excellence (NICE) guidelines phenytoin should no longer be used as a first-line treatment for epilepsy.
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