期刊
JOURNAL OF CLINICAL PHARMACOLOGY
卷 49, 期 7, 页码 768-772出版社
WILEY
DOI: 10.1177/0091270009335767
关键词
Cardiac index; hepatic blood flow; hypnotics; pharmacokinetics
资金
- NIA NIH HHS [AG-17880] Funding Source: Medline
- NIGMS NIH HHS [R01 GM055082, GM 31569-22, GM 2500-30, GM 55082-9] Funding Source: Medline
Propofol pharmacokinetics were examined in 17 adults with major burns during the hyperdynamic convalescent phase. Eighteen nonburned surgical patients served as controls. After a 2-mg/kg intravenous dose of propofol, blood samples were collected at multiple time points. Noncompartmental methods were used to calculate the pharmacokinetic parameters. The following indices were higher in burns than controls: propofol clearance (64 +/- 17 vs 29 +/- 4 mL/kg/min, P < .001) and volume of distribution (8 +/- 3 vs 4 +/- 1 L/kg, P < .001). The area under the curve was smaller in burns (556 +/- 152 vs 1193 +/- 183 mu g/mL h, P < .001). The higher clearance of propofol in burned patients may imply that these patients require higher doses or infusion rates of propofol to attain a target plasma concentration or pharmacodynamic effect.
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