Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study

AimThe aim of this randomized placebo-controlled clinical trial was to evaluate the effects of Lactobacillus reuteri-containing probiotic lozenges as an adjunct to scaling and root planing (SRP). Material and MethodsThirty chronic periodontitis patients were recruited and monitored clinically and microbiologically at baseline, 3, 6, 9 and 12weeks after therapy. All patients received one-stage full-mouth disinfection and randomly assigned over a test (SRP+probiotic, n=15) or control (SRP+placebo, n=15) group. The lozenges were used two times a day for 12weeks. ResultsAt week 12, all clinical parameters were significantly reduced in both groups, while there was significantly more pocket depth reduction (p<0.05) and attachment gain (p<0.05) in moderate and deep pockets; more Porphyromonas gingivalis reduction was observed in the SRP+probiotic group. ConclusionsThe results indicate that oral administration of L. reuteri lozenges could be a useful adjunct to SRP in chronic periodontitis.