Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs

AimThe objective of this study was to determine the efficacy of bone morphogenetic protein 2 (BMP-2) in a bovine hydroxyapatite/collagen (BHC) carrier to augment bone formation in a canine nasal sinus model. MethodsEight mongrel dogs, approximately 12months old and 30kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with E. coli-derived BMP-2 at 0.1mg/ml was implanted in four animals, and BHC loaded with E. coli-derived BMP-2 at 0.5 and 1.5mg/ml was implanted in four animals. The animals were euthanized at 20weeks when block sections were obtained for micro-computed tomography and histometric analyses. ResultsTotal augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the BMP-2 groups compared with control. ConclusionBMP-2 in a BHC carrier, even at the low 0.1-mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.