期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 39, 期 12, 页码 1125-1131出版社
WILEY-BLACKWELL
DOI: 10.1111/jcpe.12014
关键词
matrix metalloproteinases; metabolic syndrome; molecular epidemiology; periodontitis
资金
- Korea Science and Engineering Foundation (KOSEF) of the Ministry of Education, Science and Technology [2011-0017997]
- National Research Foundation of Korea, through the Oromaxillofacial Dysfunction Research Center for the Elderly at Seoul National University in Korea [2011-0028230]
- Ministry of Environment [900-20060032]
- Seoul National University School of Dentistry in Korea
Background Metabolic syndrome (MetS) may be associated with periodontitis. This study aimed to investigate whether the existence of periodontitis and MetS is cross-sectionally associated with matrix metalloproteinase (MMP) in gingival crevicular fluid (GCF) among community Koreans. Materials and Methods Medical and periodontal parameters were evaluated by physicians and dentists in 314 subjects (199 healthy, 58 only periodontitis, 34 only MetS and 23 both). The community periodontal index was used to assess periodontitis. MMP-8, 9, 13 were determined by enzyme-linked immunosorbent assay. Age, gender, monthly household income, smoking and drinking were interviewed as confounders. Analysis of covariance (ANCOVA) was applied. Gender-stratified analyses were applied. Results After controlling for various confounders, MMP-8, MMP-9 and MMP-13 in GCF were significantly associated with periodontitis in both genders and MMP-9, MMP-13 were associated with MetS in women. MMP-8, MMP-9 and MMP-13 showed association with periodontitisMetS coexistence non-synergistically in both genders. MMP-9 was synergistically associated with periodontitisMetS coexistence in women. Conclusion Our results suggest that MMP-8, MMP-9, MMP-13 in GCF were independently related to coexistence of periodontitis and MetS. MMP-9 and MMP-13 could be an appropriate common indicator of periodontitis and MetS in women. Further studies might guarantee that MMPs in GCF could screen periodontitis and MetS.
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