Systematic review of pre-clinical models assessing implant integration in locally compromised sites and/or systemically compromised animals

Objective: The aim was to systematically search the dental literature for pre-clinical models assessing implant integration in locally compromised sites (part 1) and systemically compromised animals (part 2), and to evaluate the quality of reporting of included publications. Methods: A Medline search (1966-2011) was performed, complimented by additional hand searching. The quality of reporting of the included publications was evaluated using the 20 items of the ARRIVE (Animals in Research In Vivo Experiments) guidelines. Results: One-hundred and seventy-six (part 1; mean ARRIVE score = 15.6 +/- 2.4) and 104 (part 2; 16.2 +/- 1.9) studies met the inclusion criteria. The overall mean score for all included studies amounted to 15.8 +/- 2.2. Housing (38.3%), allocation of animals (37.9%), numbers analysed (50%) and adverse events (51.4%) of the ARRIVE guidelines were the least reported. Statistically significant differences in mean ARRIVE scores were found depending on the publication date (p < 0.05), with the highest score of 16.7 +/- 1.6 for studies published within the last 2 years. Conclusions: A large number of studies met the inclusion criteria. The ARRIVE scores revealed heterogeneity and missing information for selected items in more than 50% of the publications. The quality of reporting shifted towards betterreported pre-clinical trials within recent years.