期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 37, 期 9, 页码 848-854出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-051X.2010.01585.x
关键词
C reactive protein; cystatin C; periodontal disease; periodontal surgery; systemic inflammation
资金
- Unit of Dentistry and Oral Surgery of the University of Pisa
- Department of Health's NIHR Biomedical Research Centre
- UK Clinical Research Collaboration
P>Aim To describe the kinetics of serum inflammatory markers after a course of treatment comprising surgical and non-surgical treatment of chronic periodontitis (CP). Material and Methods Fourteen CP cases received full-mouth non-surgical treatment and, after 6 months, at least two surgical sessions. Blood samples were collected at various time-points after treatment. Blood markers of systemic inflammation/coagulation including leucocyte counts, C-reactive protein (CRP), serum amyloid-A (SAA) and D-dimers and renal function (cystatin C) were determined using high-sensitivity assays. Results Periodontal treatment resulted in substantial reductions of the number of pockets, gingival bleeding and plaque at 3 and 6 months after non-surgical therapy (p < 0.001). Surgical therapy led to an additional reduction of periodontal pockets (p < 0.01). Marked increases in the serum levels of CRP and SAA were noted 24 h after non-surgical therapy (p < 0.01) and periodontal surgeries (p < 0.05). D-dimer levels increased drastically 24 h after non-surgical therapy (p < 0.05). The drastic increase of CRP after non-surgical therapy was greater than both the surgical therapy sessions (p < 0.05). Conclusions Patients undergoing periodontal treatment experience perturbations of systemic inflammation of a greater magnitude after non-surgical than surgical periodontal therapy.
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