期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 35, 期 10, 页码 853-861出版社
WILEY
DOI: 10.1111/j.1600-051X.2008.01309.x
关键词
cortisol; dehydroepiandrosterone sulphate; elderly; periodontitis; serum
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [17592186, 19659555]
- Grants-in-Aid for Scientific Research [17592186, 19659555] Funding Source: KAKEN
Background and Aim: The associations between periodontitis and stress-related steroid hormone levels released by the hypothalamic-pituitary-adrenal axis are poorly understood. In this study, we examined the association between levels of the stress-related steroid hormones cortisol and dehydroepiandrosterone-sulphate (DHEAS) and periodontitis in elderly subjects. Methods: A total of 467 subjects participated in this study. Serum cortisol and DHEAS levels were determined, and a medical questionnaire regarding medical conditions and lifestyle was administered. In addition, clinical examinations including probing depth (PD), bleeding on probing (BOP), and clinical attachment loss (CAL) were conducted. Results: The subjects were divided into tertiles on the basis of periodontitis severity. When the analysis was stratified by smoking status, we found that cortisol levels were significantly higher in those with severe CAL among subjects who had never smoked. Furthermore, multiple regression analysis showed that a higher level of cortisol was significantly associated with greater numbers of sites with severe CAL only in those who had never smoked, while a somewhat weaker association was also observed regarding cortisol/DHEAS ratio. In contrast, the level of DHEAS in serum was not associated with periodontitis. Conclusion: There were significant associations between serum cortisol level, including cortisol/DHEAS ratio, and periodontitis severity in elderly subjects who had never smoked.
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