期刊
JOURNAL OF CLINICAL PATHOLOGY
卷 62, 期 9, 页码 777-785出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jcp.2008.056101
关键词
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类别
资金
- Fondo de Investigaciones Sanitarias, Ministerio de Sanidad y Consumo [CP05/00028, FI05/00191, FI08/00012]
- Fundacio Alicia Cuello de Merigo
- [FISPI060577]
- [FISPI070304]
- [FISPI070276]
- [SAF200210529-E]
- [Marato de TV3 2005-47]
- [2004XT00090]
- [RD06/0020/1034]
This article reviews the main molecular alterations involved in endometrial carcinoma. Five molecular features (microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and beta-catenin genes) are characteristic of endometrioid carcinomas, whereas non-endometrioid carcinomas show alterations of p53, loss of heterozygosity (LOH) on several chromosomes, as well as other molecular alterations (STK15, p16, E-cadherin and C-erb B2). The review also covers the phenomenon of apoptosis resistance, as well as the results obtained from cDNA array studies, and the perspectives for targeted therapies. A group of practical applications of molecular pathology techniques are also mentioned: diagnosis of hereditary non-polyposis colon cancer syndrome in patients with endometrial carcinoma; evaluation of precursor lesions; prognosis; diagnosis, particularly for synchronous endometrioid carcinomas of the uterus and the ovaries; and targeted therapies.
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