期刊
NEW JOURNAL OF CHEMISTRY
卷 39, 期 7, 页码 5050-5074出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nj00462d
关键词
-
Glycosidases are extremely widespread enzymes responsible for the cleavage of glycosidic bonds in glycoconjugates found in living organisms. Although it was well-known that the naturally occurring iminosugars are powerful glycosidase inhibitors, the development of inhibitors based on iminosugar clusters was not explored for a long period of time. However, over the past few years, several studies demonstrated that multivalent iminosugars can strongly inhibit the above-mentioned enzymes. In this review, we will focus on the different strategies developed to synthesize these multivalent architectures, from the total synthesis of divalent iminosugars to the preparation of complex systems bearing twenty-five iminosugar units. The enzyme inhibitory properties of the various multivalent iminosugars prepared to date will also be compared in order to infer the valence and the three-dimensional arrangement required for the most efficient inhibition activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据