相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program
Richard Lock et al.
PEDIATRIC BLOOD & CANCER (2008)
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
Mai Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Chemokines in tumor angiogenesis and metastasis
Seema Singh et al.
CANCER AND METASTASIS REVIEWS (2007)
Bcl-2 orchestrates a cross-talk between endothelial and tumor cells that promotes tumor growth
Tomoatsu Kaneko et al.
CANCER RESEARCH (2007)
Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model
S. M. Guichard et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2007)
Level of endothelial cell apoptosis required for a significant decrease in microvessel density
Zhihong Dong et al.
EXPERIMENTAL CELL RESEARCH (2007)
2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition
Pamela S. Schwartz et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Bcl-2 and Bax expression predict prostate cancer outcome in men treated with androgen deprivation and radiotherapy on Radiation Therapy Oncology Group protocol 92-02
Li Yan Khor et al.
CLINICAL CANCER RESEARCH (2007)
The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
Patricia Perez-Galan et al.
BLOOD (2007)
Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX
O. Nehls et al.
BRITISH JOURNAL OF CANCER (2007)
Chemokines as mediators of angiogenesis
Borna Mehrad et al.
THROMBOSIS AND HAEMOSTASIS (2007)
Prognostic significance of bcl-2 expression in stage III breast cancer patients who had received doxorubicin and cyclophosphamide followed by paclitaxel as adjuvant chemotherapy
Kyung-Hun Lee et al.
BMC CANCER (2007)
Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1
Ramzi M. Mohammad et al.
CLINICAL CANCER RESEARCH (2007)
Programmed anuclear cell death delimits platelet life span
Kylie D. Mason et al.
CELL (2007)
Bcl2/bcl-xL inhibitor engenders apoptosis and increases chemosensitivity in mesothelioma
Xiaobo Cao et al.
CANCER BIOLOGY & THERAPY (2007)
Molecular mechanisms of resistance and toxicity associated with platinating agents
Cara A. Rabik et al.
CANCER TREATMENT REVIEWS (2007)
Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor
J. An et al.
ONCOGENE (2007)
The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan
Suzanne Trudel et al.
CLINICAL CANCER RESEARCH (2007)
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing bak activation and bax translocation
Shuang Chen et al.
CANCER RESEARCH (2007)
Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts
Satoshi Anai et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Larger than life: Mitochondria and the Bcl-2 family
Joanna Skommer et al.
LEUKEMIA RESEARCH (2007)
A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species
Monique Verhaegen et al.
CANCER RESEARCH (2006)
A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro
Kyoung Joon Oh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells
Clara Campas et al.
EXPERIMENTAL HEMATOLOGY (2006)
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Mark F. van Delft et al.
CANCER CELL (2006)
Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
Marina Konopleva et al.
CANCER CELL (2006)
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (vol 103, pg 14907, 2006)
Junya Kuroda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins
Guoping Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
Junya Kuroda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2
Benjamin D. Zeitlin et al.
CANCER RESEARCH (2006)
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins
D. Zhai et al.
CELL DEATH AND DIFFERENTIATION (2006)
Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma
Francesca Spinella et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis
G Peng et al.
MOLECULAR CARCINOGENESIS (2006)
(-)-Gossypol inhibits growth and promotes apoptosis of human head and neck squamous cell carcinoma in vivo
Keith G. Wolter et al.
NEOPLASIA (2006)
HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells
J Skommer et al.
LEUKEMIA RESEARCH (2006)
The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death
F Manero et al.
CANCER RESEARCH (2006)
Apoptosis and melanoma: how new insights are effecting the development of new therapies for melanoma
P Hersey
CURRENT OPINION IN ONCOLOGY (2006)
How the Bcl-2 family of proteins interact to regulate apoptosis
MF van Delft et al.
CELL RESEARCH (2006)
Estimation of prognostic value of Bcl-x(L) gene expression in non-small cell lung cancer
B Karczmarek-Borowska et al.
LUNG CANCER (2006)
Antisense strategies for oncogene inactivation
CA Stein et al.
SEMINARS IN ONCOLOGY (2005)
Redox properties of tea polyphenols and related biological activities
SM Sang et al.
ANTIOXIDANTS & REDOX SIGNALING (2005)
Preclinical pharmacology of 2-methoxyantimycin A compounds as novel antitumor agents
H Wang et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2005)
VEGF-induced survival of chronic lymphocytic leukemia is independent of Bcl-2 phosphorylation
L Wang et al.
LEUKEMIA (2005)
Variation in transcriptional regulation of cyclin dependent kinase inhibitor p21waf1/cipI among human bronchogenic carcinomas
Michael W. Harr et al.
MOLECULAR CANCER (2005)
Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells:: role of wild-type p53 and Bcl-XL
JA Bauer et al.
MOLECULAR CANCER THERAPEUTICS (2005)
Bcl-2 promotes invasion and lung metastasis by inducing matrix metalloproteinase-2
J Choi et al.
CANCER RESEARCH (2005)
Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-κB and CXC chemokines
E Karl et al.
CANCER RESEARCH (2005)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Green tea and the skin
S Hsu
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2005)
Cellular processing of platinum anticancer drugs
D Wang et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
The antifolate activity of tea catechins
E Navarro-Perán et al.
CANCER RESEARCH (2005)
Mcl-1
J Michels et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)
Expression of p53, Ki-67 and bcl-2 in parathyroid adenoma and residual normal tissue
T Hadar et al.
PATHOLOGY & ONCOLOGY RESEARCH (2005)
A receptor for green tea polyphenol EGCG
H Tachibana et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Bcl-XL mutations suppress cellular sensitivity to antimycin A
MK Manion et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
LD Walensky et al.
SCIENCE (2004)
Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
O Weinreb et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2004)
A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2
Y Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells
FA Sinicrope et al.
CLINICAL CANCER RESEARCH (2004)
In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells
CL Oliver et al.
CLINICAL CANCER RESEARCH (2004)
Green tea polyphenol epigallocatechin-3-gallate inhihits platelet-derived growth factor-induced proliferation of human hepatic stellate cell line LI90
R Sakata et al.
JOURNAL OF HEPATOLOGY (2004)
Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro
PT Ferrao et al.
BLOOD (2003)
Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells
J Cai et al.
DIABETES (2003)
Treatment of melanoma cells with a bcl-2/bcl-xL antisense oligonucleotide induces antiangiogenic activity
D Del Bufalo et al.
ONCOGENE (2003)
Discovery, characterization, and structure - Activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
S Kitada et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis
B Martin et al.
BRITISH JOURNAL OF CANCER (2003)
Measurement of chemoresistance markers in patients with stage III non-small cell lung cancer: A novel approach for patient selection
KR Brooks et al.
ANNALS OF THORACIC SURGERY (2003)
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells
MC Zhang et al.
BIOCHEMICAL PHARMACOLOGY (2003)
HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death
JD Lickliter et al.
LEUKEMIA (2003)
Bcl-XL deamidation is a critical switch in the regulation of the response to DNA damage
BE Deverman et al.
CELL (2002)
Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity
A Iervolino et al.
FASEB JOURNAL (2002)
Keeping killers on a tight leash: transcriptional and posttranslational control of the pro-apoptotic activity of BH3-only proteins
H Puthalakath et al.
CELL DEATH AND DIFFERENTIATION (2002)
Role of the retinoblastoma (pRb)-E2F/DP pathway in cancer chemopreventive effects of green tea polyphenol epigallocatechin-3-gallate
N Ahmad et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)
Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells
GP Pidgeon et al.
BRITISH JOURNAL OF CANCER (2001)
Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4
Y Yu et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A
KM Kim et al.
BIOCHEMISTRY (2001)
Oral gossypol in the treatment of patients with refractory metastatic breast cancer: A phase I/II clinical trial
C Van Poznak et al.
BREAST CANCER RESEARCH AND TREATMENT (2001)
EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells
YD Jung et al.
BRITISH JOURNAL OF CANCER (2001)
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3
SP Tzung et al.
NATURE CELL BIOLOGY (2001)
Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells
MH Pan et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2000)
Cytotoxic effect of gossypol on colon carcinoma cells
XH Wang et al.
LIFE SCIENCES (2000)
Angiogenesis in cancer and other diseases
P Carmeliet et al.
NATURE (2000)
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
JL Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive - A multicenter, international, dose-finding study
EM Coutinho et al.
CONTRACEPTION (2000)