期刊
JOURNAL OF CLINICAL ONCOLOGY
卷 26, 期 27, 页码 4449-4457出版社
AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2007.15.4385
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资金
- National Institutes of Health [CA72064, CA42045, CA90771]
Purpose Patients with locally advanced breast carcinoma (LABC) receive preoperative chemotherapy to provide early systemic treatment and assess in vivo tumor response. Serial positron emission tomography (PET) has been shown to predict pathologic response in this setting. We evaluated serial quantitative PET tumor blood flow (BF) and metabolism as in vivo measurements to predict patient outcome. Patients and Methods Fifty-three women with primary LABC underwent dynamic [F-18] fluorodeoxyglucose (FDG) and [O-15] water PET scans before and at midpoint of neoadjuvant chemotherapy. The FDG metabolic rate (MRFDG) and transport ( FDG K-1) parameters were calculated; BF was estimated from the [O-15] water study. Associations between BF, MRFDG, FDG K-1, and standardized uptake value and disease-free survival (DFS) and overall survival (OS) were evaluated using the Cox proportional hazards model. Results Patients with persistent or elevated BF and FDG K-1 from baseline to midtherapy had higher recurrence and mortality risks than patients with reductions. In multivariable analyses, BF and FDG K-1 changes remained independent prognosticators of DFS and OS. For example, in the association between BF and mortality, a patient with a 5% increase in tumor BF had a 67% higher mortality risk compared with a patient with a 5% decrease in tumor BF (hazard ratio = 1.67; 95% CI, 1.24 to 2.24; P < .001). Conclusion LABC patients with limited or no decline in BF and FDG K-1 experienced higher recurrence and mortality risks that were greater than the effects of clinical tumor characteristics. Tumor perfusion changes over the course of neoadjuvant chemotherapy measured directly by [O-15] water or indirectly by dynamic FDG predict DFS and OS.
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