期刊
JOURNAL OF CLINICAL ONCOLOGY
卷 26, 期 18, 页码 3031-3037出版社
AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2007.14.6399
关键词
-
类别
资金
- NCI NIH HHS [CA21765, CA 78224, CA 51001] Funding Source: Medline
- NHLBI NIH HHS [U01 HL65899, U01 HL065899] Funding Source: Medline
- NIGMS NIH HHS [U01 GM61393, U01GM61374] Funding Source: Medline
- NCHHSTP CDC HHS [PS207386] Funding Source: Medline
Purpose Corticosteroids are a critical component of therapy for acute lymphoblastic leukemia (ALL) but are associated with late effects, such as osteoporosis. Risk factors remain poorly defined. Because CRHR1 polymorphisms have been associated with other corticosteroid effects, our goal was to define whether CRHR1 polymorphisms predict which patients with ALL are likely to develop bone mineral deficits. Patients and Methods The mean bone mineral density z scores of 309 long-term survivors of ALL were determined by quantitative computed tomography of the trabecular lumbar spine. We analyzed whether CRHR1 genotypes, adjusted for sex, ALL treatment regimen, and weight, could predict bone density. Results We found that three single nucleotide polymorphisms (SNPs), all in linkage disequilibrium, were associated with bone density in a sex-specific manner. Bone density was lower in males (P = .001), in nonblack patients (P < .08), in those who were not overweight (P < .001), and in those who received intensive antimetabolites and glucocorticoids (P < .001). After adjustment for these features, the G allele at the rs1876828 SNP was associated with lower z scores (P = .02) in males but tended to have the opposite association in females (P = .09). Conclusion CRHR1 polymorphisms may impact the risk of bone density deficits in patients treated with corticosteroids and antimetabolites in a sex-specific manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据