期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 52, 期 5, 页码 1730-1736出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.03138-13
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资金
- Key National Basic Research Program of China [2012CB619101]
- Major Basic Research of Science and Technology Commission of Shanghai Municipality [11DJ1400303]
- National Natural Science Foundation of China [81190133]
- Key Disciplines of Shanghai Municipal Education Commission [J50206]
- scientific research grant for youth of Shanghai [ZZjdyx 2097]
- 985 Project-Stem Cell and Regenerative Medicine Centre
- Zhejiang National Science Foundation [Y2110653]
This meta-analysis included 12 studies that evaluated sonication fluid cultures (SFC) for the diagnosis of prosthetic joint infection (PJI). The pooled sensitivity and specificity were 0.80 (95% confidence interval [CI], 0.74 to 0.84) and 0.95 (CI, 0.90 to 0.98), respectively. Subgroup analyses showed that a 14-day anaerobic culture may improve sensitivity, the use of centrifugation or vortexing may improve specificity, and the use of 400 to 500 ml of Ringer's solution for containers may improve sensitivity and specificity. The best SFC cutoff was >= 5 CFU. In conclusion, SFC has high sensitivity and very high specificity for diagnosing PJI.
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