期刊
NEUROTOXICOLOGY AND TERATOLOGY
卷 52, 期 -, 页码 151-161出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ntt.2015.08.001
关键词
Flame retardants; Human exposure; Mexican; Prenatal; ADHD; Attention; Executive function; Neurodevelopment; Motor skills; Biomarkers; Children; Human blood serum; Flammability standard; Flammability
资金
- U.S. Environmental Protection Agency (US EPA) [RD 83171001, RD 826709]
- NIEHS [PO1 ES009605, RO1 ES015572]
Objective: California children's exposures to polybrominated diphenyl ether flame retardants (PBDEs) are among the highest measured worldwide. We previously reported associations for prenatal and childhood PBDE exposures with decrements in attention, processing speed, fine motor coordination, and cognition in children at ages 5 and 7 years. Here, we investigate associations of PBDEs with attention and executive function at ages 9 to 12 years in the expanded CHAMACOS cohort. Methods: We measured PBDEs in prenatal and child age 9 year serum samples for families enrolled in the study since pregnancy (CHAM1, N = 321). In a subsequent cohort for which families were enrolled at child age 9 (CHAM2, N = 301), we measured PBDEs in maternal and child samples collected at child age 9, and used predictive modeling to estimate prenatal exposure levels. We examined associations of measured and estimated PBDE concentrations on children's attention and executive functioning at ages 9, 101/2, and 12 years. Results: Geometric rneans for prenatal and childhood Sigma PBDE levels (sum of PBDE-47, -99, -100, -153) for the expanded CHAMACOS cohort were 26.3 and 632 ng/g lipid, respectively, and did not differ significantly between CHAM1 and CHAIVI2 families. We found consistent associations of prenatal exposure to PBDEs with poorer attention and executive function, measured with parent report and direct neuropsychological testing of the child. For example, using GEE models of repeated outcome measures at ages 9 and 123 a 10-fold increase in prenatal Sigma PBDE was associated with poorer response consistency on the Conners' Continuous Performance Test II (beta = 2.9; 95% CI: 0.9, 4.8) and poorer working memory on the Behavioral Rating Inventory of Executive Function (beta = 2.5; 95% CI: 0.5, 4.4). Child age 9 Sigma PBDE levels were associated with poorer parent-reported attention and executive function for girls but not boys. Conclusions: Our results suggest that the prefrontal cortex may be a potential target for PBDE exposure and add to a growing literature showing that these ubiquitous toxicants may adversely affect neurodevelopment. (C) 2015 Elsevier Inc. All rights reserved.
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