期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 52, 期 6, 页码 2172-2174出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00189-14
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资金
- Forest Pharmaceuticals.
- Cubist Pharmaceuticals
- NICHD Developmental and Translational Pharmacology of Pediatric Antimicrobial Therapy grant [U54 HD071600-01]
- Great Lakes Regional Center for Excellence in Biodefense and Emerging Infectious Disease Research grant [AI057153]
Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virulent health care-associated MRSA strains may coevolve innate host defense peptide and antibiotic resistances.
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