期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 52, 期 1, 页码 298-301出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02274-13
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资金
- U.S. Army Medical Materiel Development Activity, Fort Detrick, MD
- National Institutes of Health [AI089819]
- University of North Carolina Summer Undergraduate Research Fellowship
- ASTMH/Burroughs Wellcome Postdoctoral Fellowship in Tropical Infectious Disease
- North Carolina Clinical and Translational Science Award [UL1RR025747]
A heteroduplex tracking assay used to genotype Plasmodium vivax merozoite surface protein 1 was adapted to a capillary electrophoresis format, obviating the need for radiolabeled probes and allowing its use in settings where malaria is endemic. This new assay achieved good allelic discrimination and detected high multiplicities of infection in 63 P. vivax infections in Cambodia. More than half of the recurrent parasitemias sampled displayed identical or highly related genotypes compared to the initial genotype, suggesting that they represented relapses.
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