期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 50, 期 11, 页码 3641-3651出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02248-12
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- Spanish Society for Clinical Microbiology and Infectious Diseases (SEIMC, Spain)
- European Consortium of Microbial Resource Centres (EMbaRC)
- Fondo de Investigaciones Sanitarias (Spain) [CM08/0083]
- Spanish Network for Research in Infectious Diseases (REIPI) [RD06/0008]
The Candida haemulonii species complex is currently known as C. haemulonii groups I and II. Here we describe C. haemulonii group II as a new species, Candida duobushaemulonii sp. nov., and C. haemulonii var. vulnera as new a variety of C. haemulonii group I using phenotypic and molecular methods. These taxa and other relatives of C. haemulonii (i.e., Candida auris and Candida pseudohaemulonii) cannot be differentiated by the commercial methods now used for yeast identification. Four isolates (C. haemulonii var. vulnera) differed from the other isolates of C. haemulonii in the sequence of the internal transcribed spacer (ITS) regions of the nuclear rRNA gene operon. The new species and the new variety have a multiresistant antifungal profile, which includes high MICs of amphotericin B (geometric mean MIC, 1.18 mg/liter for C. haemulonii var. vulnera and 2 mg/liter for C. duobushaemulonii sp. nov) and cross-resistance to azole compounds. Identification of these species should be based on molecular methods, such as sequence analysis of ITS regions and matrix-assisted laser desorption ionization-time of flight mass spectrometry.
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