期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 50, 期 4, 页码 1471-1474出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.05793-11
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- National Major Science and Technology Project for the Prevention and Treatment of AIDS and Viral Hepatitis and Other Major Infectious Diseases [2008ZX10003-005]
The presence of heteroresistance was represented by 23% of 235 fluoroquinolone (FQ)-resistant Mycobacterium tuberculosis isolates in Beijing, China, from 2008 to 2010. The main mechanism of FQ heteroresistance is due to the segregation of a single M. tuberculosis strain in patients; the majority of isolates with multidrug-resistant tuberculosis contained a mixture of bacterial subpopulations consisting of various mutant types, suggesting that the improper use of FQ is the major cause of FQ resistance.
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