4.7 Article

Rapid Whole-Genome Sequencing for Investigation of a Suspected Tuberculosis Outbreak

期刊

JOURNAL OF CLINICAL MICROBIOLOGY
卷 51, 期 2, 页码 611-614

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02279-12

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资金

  1. United Kingdom Clinical Research Collaboration (UKCRC) Translational Infection Research Initiative (TIRI)
  2. Medical Research Council [G1000803]
  3. Biotechnology and Biological Sciences Research Council
  4. National Institute for Health Research (NIHR) on behalf of the United Kingdom Department of Health
  5. Health Protection Agency
  6. NIHR Cambridge Biomedical Research Centre
  7. Wellcome Trust
  8. Oxford University Press
  9. Medical Research Council [G1000803] Funding Source: researchfish
  10. MRC [G1000803] Funding Source: UKRI

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Two Southeast Asian students attending the same school in the United Kingdom presented with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, and drug resistance profiles of the Mycobacterium tuberculosis isolates were discrepant. Whole-genome sequencing of the isolates found them to be genetically identical, suggesting a missed transmission event.

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