期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 49, 期 4, 页码 1588-1590出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00113-11
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- National Health and Education Society, P. D. Hinduja National Hospital and Medical Research Centre, Mumbai, India
We screened and spoligotyped 150 consecutive phenotypically confirmed extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) isolates (January 2008 to March 2009) for rifampin, isoniazid, fluoroquinolone, and aminoglycoside resistance targeting rpoB, inhA, katG, gyrA, gyrB, and rrs. Mutations predominant among XDR-TB were S315T (katG) (100% of isolates), S531L (rpoB) (97% of isolates), D94G (gyrA) (53% of isolates), and A1401G (rrs) (71% of isolates). Spoligotyping revealed 62% of the isolates to be Beijing.
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