期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 46, 期 4, 页码 1514-1516出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01938-07
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- PHS HHS [R21 A155800-01] Funding Source: Medline
- Wellcome Trust [072402/Z/03/Z] Funding Source: Medline
The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations.
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