期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 46, 期 3, 页码 882-886出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01079-07
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- NCRR NIH HHS [M01 RR000032] Funding Source: Medline
- NIDCD NIH HHS [R01 DC04163, R01 DC004163] Funding Source: Medline
- PHS HHS [M01 R00032] Funding Source: Medline
Infection and reinfection with multiple cytomegalovirus (CMV) strains have been shown to occur in immunocompromised individuals, sexually transmitted disease clinic attendees, and children attending day care centers. To characterize the CMV diversity in healthy seropositive individuals, 16 CMV PCR-positive specimens from 113 seropositive women were analyzed for glycoprotein gN and gB genotypes by cloning, followed by nucleotide sequencing of the plasmid DNA and/or restriction fragment length pollymorphism (RFLP). The results showed that most (93.7%) of the PCR-positive specimens contained multiple gN and/or gB genomic variants, suggesting that the majority of women were infected with more than one virus strain. The results also showed that the RFLP technique might not be sufficiently sensitive to detect all of the genomic variants present in a sample.
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