期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 46, 期 4, 页码 1466-1469出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.02241-07
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- Wellcome Trust [049366/Z/96/Z] Funding Source: Medline
First-void urine (FVU) is the preferred specimen for the diagnosis of urogenital Chlamydia trachomatis infection in men. We have developed FirstBurst, a urine collection device that collects the first 4 to 5 ml of FVU and yields a specimen with a sixfold higher C trachomatis organism load than the regular urine cup by quantitative PCR (32,533 versus 5,271 plasmids/ml; P < 0.0001). Consequently, the use of FirstBurst to collect a urine sample improved the sensitivity of a rapid test for Chlamydia over testing of samples collected with a urine cup (82 versus 47% sensitivity using PCR as a reference; P < 0.0015).
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