期刊
JOURNAL OF CLINICAL LIPIDOLOGY
卷 4, 期 5, 页码 371-375出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacl.2010.08.005
关键词
Inflammation; Macrophage; Host defense mechanisms; ApoE; ABCA1; ABCG1; Cholesterol; Oxidation
资金
- NHLBI NIH HHS [R01 HL086798, R01 HL086798-05] Funding Source: Medline
High-density lipoprotein (HDL) is proposed to inhibit atherosclerosis via a number of different pathways, including promotion of reverse cholesterol transport and inhibition of inflammation. However, studies in both mice and humans suggest that quantifying HDL-cholesterol (HDL-C) levels provide limited information regarding the cardioprotective effects of HDL. This article briefly reviews current thinking regarding the functional and cardioprotective effects of HDL and the role of the HDL proteome in these processes. (C) 2010 National Lipid Association. All rights reserved.
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