期刊
JOURNAL OF CLINICAL LIPIDOLOGY
卷 4, 期 5, 页码 405-410出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacl.2010.08.012
关键词
High density lipoprotein; HDL particles; HDL-C; CHD; Niacin; HDL raising
The use of statins in patients with high risk for cardiovascular disease (CVD) has resulted in a 30-40% decrease in clinical events in the last couple of decades. However, despite of a marked reduction (up to 60%) in LDL-C, about 30% of patients continue to have CVD events. This high residual risk in statin-treated patients initiated the search for new ways to reduce CVD risk. HDL is the next logical target. Epidemiological and cross-sectional studies identified low HDL-C level as an independent risk for CVD.(1,2) Based on the Framingham Heart Study data, HDL-C <35 mg/dl was established an independent risk factor and HDL-C >60 mg/dl as protective.(3) Presently the cut point is <40 mg/dl for men and <50 mg/dl for women. (C) 2010 National Lipid Association. All rights reserved.
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