Serum Lipid Profile, Oxidative Status, and Paraoxonase 1 Activity in Hyperemesis Gravidarum

The aim of this study was to investigate lipid profile, paraoxonase 1 (PON1) activity, and oxidative stress status in the serum of hyperemesis gravidarum (HG) patients. Thirty-six HG cases and 36 normal pregnants were included in the study. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apoproteins A1 (apo A1) and B (apo 6), malondialdehyde (MDA), and total antioxidant activity (TAO) values and PON1 and arylesterase activities were determined. Although serum TC, TG, LDL-C, and apo B levels were not different among; the groups (P > 0.05), HDL-C (P = 0.01) and apo A1 (P = 0.007) levels were lower in HG patients than in normal pregnants. HG group had significantly lower serum PON1 (P = 0.03) and arylesterase activities (P = 0.03) compared with the control group. Additionally, mean TAO values were lower (P = 0.01) and MDA levels were higher (P = 0.02) in HG group than in the healthy pregnants. A significant negative correlation between POW and MDA was found in HG group (r = -0.33, P < 0.05). The findings of this study have revealed that HG may be one of the conditions in which oxidant and antioxidant balance is impaired. J. Clin. Lab. Anal. 23:105-109, 2009. (C) 2009 Wiley-Liss, Inc.