期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 128, 期 9, 页码 3704-3715出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI120847
关键词
-
资金
- NIH [F30 HL139017, R01 HL124021, HL 122596, HL 138437, UH2 TR002073]
- American Heart Association grant [18EIA33900027]
Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature, where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the Warburg effect in cancer, a shift from mitochondrial oxidation to glycolysis occurs in diseased pulmonary vessels and the right ventricle. However, appreciation of metabolic events in PH beyond the Warburg effect is only just emerging. This Review discusses molecular, translational, and clinical concepts centered on the mitochondria and highlights promising, controversial, and challenging areas of investigation. If we can move beyond the mountains of obstacles in this field and elucidate these fundamental tenets of pulmonary vascular metabolism, such work has the potential to usher in much-needed diagnostic and therapeutic approaches for the mitochondrial and metabolic management of PH.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据