期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 124, 期 11, 页码 4678-4680出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI78891
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资金
- Swiss National Foundation [320030_140772, 310030_156823]
- CK-CARE
- European 7th Framework projects Mechanisms of the Development of Allergy (MeDALL) [261357]
- Post-Infectious Immune Reprogramming and Its Association with Persistence and Chronicity of Respiratory Allergic Diseases (PREDICTA) [260895]
- Swiss National Science Foundation (SNF) [310030_156823, 320030_140772] Funding Source: Swiss National Science Foundation (SNF)
During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell tolerance, particularly that mediated by the immune-/ suppressive functions of IL-10, led to a major conceptual change in this area. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory subsets of T and B cells, the immune-suppressive function of secreted factors, such as IL-10 and TGF-beta, the production of IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues.
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