期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 124, 期 10, 页码 4173-4181出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI72335
关键词
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资金
- NIH [1F32DK101154, P50GM068763]
- Bauer Fellows program at Harvard University
Our associated microbial communities play a critical role in human health and predisposition to disease, but the degree to which they also shape therapeutic interventions is not well understood. Here, we integrate results from classic and current studies of the direct and indirect impacts of the gut microbiome on the metabolism of therapeutic-drugs and diet-derived bioactive compounds. We pay particular attention to microbial influences on host responses to xenobiotics, adding to the growing consensus that treatment outcomes reflect our intimate partnership with the microbial world, and providing an initial framework from which to consider a more comprehensive view of pharmacology and nutrition.
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