期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 124, 期 10, 页码 4190-4196出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI72330
关键词
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资金
- NIH grants [P30 DK42086, R37 DK47722, R01 DK097268, T32 DK07074, F32 DK09025]
- Leona M. and Harry B. Helmsley Charitable Trust
- Gastro-Intestinal Research Foundation of Chicago
Inflammatory bowel diseases (IBD) are chronic, progressive diseases characterized by aberrant immune responses to environmental and gut microbial triggers in genetically susceptible hosts. Clinical, genetic, and experimental data support the role of gut microbes in causing and sustaining these diseases. Our understanding of IBD has changed dramatically as the result of advances in cultivation-independent approaches and computational platforms for the analysis of large data sets. However, investigations relevant to clinical observations and the natural history of the diseases will be essential for the development of microbial, genetic, and biological metrics that may be used to individualize assessment of risk and improve clinical outcomes in IBD.
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