期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 123, 期 9, 页码 3652-3658出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI67228
关键词
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资金
- Cancer Research UK
- European Research Council under the European Community [310837]
- Yamagata Prefectural Government
- City of Tsuruoka
- [22134007]
- European Research Council (ERC) [310837] Funding Source: European Research Council (ERC)
The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such oncometabolites in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.
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