期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 123, 期 7, 页码 2756-2763出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI69219
关键词
-
Immunotherapy can be an effective treatment for metastatic cancer, but a significant subpopulation will not respond, likely due to the lack of antigenic mutations or the immune-evasive properties of cancer. Likewise, radiation therapy (RT) is an established cancer treatment, but local failures still occur. Clinical observations suggest that RT may expand the therapeutic reach of immuntherapy. We examine the immunobiologic and clinical rationale for combining RT and inmumotherapy, two modalities yet to be used in combination in routine practice. Preclinical data indicate that RT can potentiate the systemic efficacy of immunotherapy, while activation of the innate and adaptive immune system can enhance the local efficacy of RT.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据