期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 123, 期 4, 页码 1405-1412出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI61398
关键词
-
资金
- NIH [NS21328, NS070298, AG24373, DK73691]
- Simon Foundation [205844]
The classical Mendelian genetic perspective has failed to adequately explain the biology and genetics of common metabolic and degenerative diseases. This is because these diseases are primarily systemic bioenergetic diseases, and the most important energy genes are located in the cytoplasmic mitochondrial DNA (mtDNA). Therefore, to understand these complex diseases, we must investigate their bioenergetic pathophysiology and consider the genetics of the thousands of copies of maternally inherited mtDNA, the more than 1,000 nuclear DNA (nDNA) bioenergetic genes, and the epigenomic and signal transduction systems that coordinate these dispersed elements of the mitochondrial genome.
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