期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 123, 期 10, 页码 4136-4139出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI72325
关键词
-
Insulin and Zn2+ enjoy a multivalent relationship. Zn2+ binds insulin in pancreatic p cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in response to physiological signals such as increased blood glucose. This transition metal is an essential cofactor in insulin-degrading enzyme and several key Zn2+ finger transcription factors that are required for beta cell development and insulin gene expression. Studies are increasingly revealing that fluctuations in Zn2+ concentration can mediate signaling events, including dynamic roles that extend beyond that of a static structural or catalytic cofactor. In this issue of the fa, Tamaki et al. propose an additional function for Zn2+ in relation to insulin: regulation of insulin clearance from the bloodstream.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据