期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 122, 期 1, 页码 229-240出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI46215
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资金
- NIH [R01HL085312, R03HL095406-01]
- NIH National Heart, Lung and Blood Institute Specialized Center [P50HL084945]
- Grace Anne Dorney fund
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P50HL084945, R03HL095406, R01HL085312] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES016285] Funding Source: NIH RePORTER
Chronic obstructive pulmonary disease (COPD) is a prevalent smoking-related disease for which no disease-altering therapies currently exist. As dysregulated TGF-beta signaling associates with lung pathology in patients with COPD and in animal models of lung injury induced by chronic exposure to cigarette smoke (CS), we postulated that inhibiting TGF-beta signaling would protect against CS-induced lung injury. We first confirmed that TGF-beta signaling was induced in the lungs of mice chronically exposed to CS as well as in COPD patient samples. Importantly, key pathological features of smoking-associated lung disease in patients, e.g., alveolar injury with overt emphysema and airway epithelial hyperplasia with fibrosis, accompanied CS-induced alveolar cell apoptosis caused by enhanced TGF-beta signaling in CS-exposed mice. Systemic administration of a TGF-beta-specific neutralizing antibody normalized TGF-beta signaling and alveolar cell death, conferring improved lung architecture and lung mechanics in CS-exposed mice. Use of losartan, an angiotensin receptor type 1 blocker used widely in the clinic and known to antagonize TGF-beta signaling, also improved oxidative stress, inflammation, metalloprotease activation and elastin remodeling. These data support our hypothesis that inhibition of TGF-beta signaling through angiotensin receptor blockade can attenuate CS-induced lung injury in an established murine model. More importantly, our findings provide a preclinical platform for the development of other TGF-beta-targeted therapies for patients with COPD.
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