期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 122, 期 8, 页码 2773-2776出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI63966
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In this issue of JCI, two independent groups describe the effects of germline and liver-specific deletion of Mir 122a, the predominant liver miRNA. Their findings reveal a critical role for miR-122 in fat and cholesterol metabolism but suggest that other metabolic actions of the liver are independent of miR-122. Knockout mice also displayed hepatic inflammation, fibrosis, and a high incidence of hepatocellular carcinoma, suggesting that miR-122 has a tumor suppressor role in hepatocytes.
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