期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 122, 期 10, 页码 3424-3431出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI63186
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资金
- National Cancer Institute of Canada (NCIC) Terry Fox Foundation Program [019001]
- Ligue Genevoise Contre le Cancer et Fondation Dr Henri Dubois-Ferriere Dinu Lipatti
The hallmark t(14;18)(q32;q21) in follicular lymphoma (FL) results in constitutive overexpression of the BCL2 protein, allowing B cells to abrogate the default germinal center apoptotic program. Most tumors are characterized by recurrent secondary genetic alterations including genomic gains, losses, and mutations, some providing a growth advantage, including alterations in MLL2, EPHA7, TNFRSF14, and EZH2. The sequence in which these events occur and how they contribute to progression and ultimately to transformation is unclear. Lastly, crosstalk between neoplastic B cells and non-neoplastic immune and stromal cells in the microenvironment plays an important role in sustaining tumor cell growth, cultivating immune privilege, and promoting transformation.
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