期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 123, 期 1, 页码 115-117出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI67238
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资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK053792] Funding Source: NIH RePORTER
- NIDDK NIH HHS [R01 DK053792] Funding Source: Medline
In response to feeding, insulin promotes the uptake of sugar in peripheral tissues and suppresses the production of sugar, a process called gluconeogenesis, in the liver. Recent research has shown that chronic inflammation promotes insulin resistance, and in turn, chronically high glucose levels can drive inflammation. In this issue of the JCI, Stanya et al. investigate the connection between inflammation and glucose homeostasis by analyzing the effect of the antiinflammatory cytokine IL-13. Their results suggest that IL-13 plays an unexpected role in the regulation of glucose homeostasis by modulating gluconeogenesis and may be a useful therapeutic target for treatment of diabetes and metabolic syndrome.
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