期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 121, 期 12, 页码 4572-4578出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI57131
关键词
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资金
- NIH [R01 DK060694]
- National Pancreas Foundation
- NIH Center for Molecular Studies in Digestive and Liver Diseases [P30-DK050306]
- NIH Diabetes and Endocrinology Research Center [P30-DK019525]
The pancreas is a complex organ comprised of three critical cell lineages: islet (endocrine), acinar, and ductal. This review will focus upon recent insights and advances in the biology of pancreatic ductal cells. In particular, emphasis will be placed upon the regulation of ductal cells by specific transcriptional factors during development as well as the underpinnings of acinar-ductal metaplasia as an important adaptive response during injury and regeneration. We also address the potential contributions of ductal cells to neoplastic transformation, specifically in pancreatic ductal adenocarcinoma.
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