期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 121, 期 6, 页码 2118-2125出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI45680
关键词
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资金
- Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology
- Merck Co.
- Life Sciences Institute of the University of Michigan
- Grants-in-Aid for Scientific Research [21591137, 21249057, 21590308] Funding Source: KAKEN
Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single beta cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.
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