期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 121, 期 1, 页码 422-430出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI44244
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资金
- American Heart Association (AHA) [0825548D]
- University of Pennsylvania, Division of Cardiology T 32 and Benjamin & Mary Siddons Measey Foundation
- AHA DeHaan Myogenesis Center
- NIH [U01 HL100405, R01 HL095634]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL095634, U01HL100405] Funding Source: NIH RePORTER
Congenital anomalies of the aortic valve are common and are associated with progressive valvular insufficiency and/or stenosis In addition, aneurysm, coarctation, and dissection of the ascending aorta and aortic arch are often associated conditions that complicate patient management and increase morbidity and mortality These associated aortopathies are commonly attributed to turbulent hemodynamic flow through the malformed valve leading to focal defects in the vessel wall However, numerous surgical and pathological studies have identified widespread cystic medial necrosis and smooth muscle apoptosis throughout the aortic arch m affected patients Here, we provide experimental evidence for an alternative model to explain the association of aortic vessel and valvular disease Using mice with primary and secondary cardiac neural crest deficiencies, we have shown that neural crest contribution to the outflow endocardial cushions (the precursors of the semilunar valves) is required for late gestation valvular remodeling, mesenchymal apoptosis, and proper valve architecture Neural crest was also shown to contribute to the smooth muscle layer of the wall of the ascending aorta and aortic arch Hence, defects of cardiac neural crest can result m functionally abnormal semilunar valves and concomitant aortic arch artery abnormalities
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