期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 121, 期 2, 页码 519-521出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI45939
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资金
- NIAID NIH HHS [R01 AI089954-01, R21 AI091962, R01 AI089954-02, R21 AI091962-01, R21 AI091962-02, AI089954, R01 AI089954, R01 AI089954-03] Funding Source: Medline
- NIDDK NIH HHS [R01 DK105562] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008061] Funding Source: Medline
Liver X receptors (LXRs) are nuclear receptors involved in cholesterol homeostasis. Notably, they are also expressed by T cells and are involved in regulating T cell proliferation and differentiation. In this issue of the JCI, Cui et al. have elucidated the molecular mechanism underlying the effects of LXR activation on a subset of T cells known as Th17 cells in mice and humans. Specifically, they showed that LXR-induced Srebp-1 inhibits 111 7 transcription by binding to the 1117 promoter through interaction with the aryl hydrocarbon receptor (Ahr), a transcription factor known to enhance Th17 cell responses.
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