期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 120, 期 11, 页码 3912-3916出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI43604
关键词
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资金
- NIH
- Donald W. Reynolds Center for Clinical Cardiovascular Research
- American Heart Association [09PRE2261344]
- Jon Holden DeHaan Foundation
- Fondation Leducq's Transatlantic Network of Excellence in Cardiovascular Research Program
- Robert A. Welch Foundation [I-0025]
MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary sequences in 3' untranslated regions of target mRNAs. MicroRNA-21 (miR-21) is upregulated in response to cardiac stress, and its inhibition by a cholesterol-modified antagomir has been reported to prevent cardiac hypertrophy and fibrosis in rodents in response to pressure overload. In contrast, we have shown here that miR-21-null mice are normal and, in response to a variety of cardiac stresses, display cardiac hypertrophy, fibrosis, upregulation of stress-responsive cardiac genes, and loss of cardiac contractility comparable to wild. type littermates. Similarly, inhibition of miR-21 through intravenous delivery of a locked nucleic acid-modified (LNA-modified) antimiR oligonucleotide also failed to block the remodeling response of the heart to stress. We therefore conclude that miR-21 is not essential for pathological cardiac remodeling.
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