期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 120, 期 2, 页码 422-432出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI38136
关键词
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资金
- INSERM
- Fondation pour la Recherche Medicale
- Vieillissement Cardiovasculaire
- Leducq Transatlantic Network
- TOLERAGE
- Societe Francaise d'Atherosclerose
Complicated abdominal aortic aneurysm (AAA) is a major cause of mortality in elderly men. Ang II-dependent TGF-beta activity promotes aortic aneurysm progression in experimental Marfan syndrome. However, the role of TGF-beta in experimental models of AAA has not been comprehensively assessed. Here, we show that systemic neutralization of TGF-beta activity breaks the resistance of normocholesterolemic CS7BL/6 mice to Ang II-induced AAA formation and markedly increases their susceptibility to the disease. These aneurysms displayed a large spectrum of complications on echography, including fissuration, double channel formation, and rupture, leading to death from aneurysm complications. The disease was refractory to inhibition of IFN-gamma, IL-4, IL-6, or TNF-alpha signaling. Genetic deletion of T and B cells or inhibition of the CX3CR1 pathway resulted in partial protection. Interestingly, neutralization of TGF-beta activity enhanced monocyte invasiveness, and monocyte depletion markedly inhibited aneurysm progression and complications. Finally, TGF-beta neutralization increased MMP-12 activity, and MMP-12 deficiency prevented aneurysm rupture. These results clearly identify a critical role for TGF-beta in the taming of the innate immune response and the preservation of vessel integrity in CS7BL/6 mice, which contrasts with its reported pathogenic role in Marfan syndrome.
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