期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 120, 期 6, 页码 1791-1799出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI42344
关键词
-
资金
- Swiss National Science Foundation [31003A-113525]
- European Union
Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironrnent. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atherosclerosis, insulin resistance, and diabetes. We discuss here the biology of urate metabolism and its role in disease. We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据