期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 120, 期 9, 页码 3073-3083出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI42440
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资金
- NATIONAL EYE INSTITUTE [ZIAEY000184] Funding Source: NIH RePORTER
Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.
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