期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 120, 期 11, 页码 3815-3817出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI45105
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资金
- NHLBI NIH HHS [R37 HL061795, HL81587, HL70819, P01 HL048743, R01 HL061795, U54 HL070819, HL61795, P01 HL081587, HL48743] Funding Source: Medline
Adaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1). HIF-1 expression is also controlled by specific microRNAs and, in turn, controls the expression of other microRNAs, which fine-tune adaptation to low oxygen tension. In this issue of the JCI, Ghosh and colleagues identify a unique microRNA in hypoxic endothelial cells, miR424, that promotes HIF-1 stabilization and angiogenesis. The actions of this microRNA are considered in the context of the complex interactions that act to ensure optimal endothelial adaptation to this critical environmental condition.
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