期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 119, 期 6, 页码 1420-1428出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI39104
关键词
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资金
- NIH [DK55001, DK62978, DK61688, AA13913, CA125550, U54 CA12515, R01 CA078461]
- Division of Matrix Biology at Beth Israel Deaconess Medical Center
- Ludwig Center for Molecular Oncology at Massachusetts Institute of Technology
The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. However, emerging evidence suggests that epithelial-mesenchymal transitions (EMTs) represent one important source of these cells. As we discuss here, processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias. The identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions.
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